![]() And what you have to do is to fly a lot to receive money rewards to buy tools to upgrade your potty plane. Like the before to version, that guy start to try to fly with a porta potty. And of course, your mission is still the same, but his dream had a great change. In the before two version, you helped him fly in long distances and great height, but now, his dream is much bigger. As you know, in the series of the games, you play as a guy who desires to fly. The potty racers 3 is the third version of the series Potty racers. Why don’t you try playing such an incredible game like Potty racers 3 now? You will be blown away immediately! The potty racers 3 is here!!! It is an amazing game! Anybody who plays this game will fall in love with it. Tags: Potty Racers 2, potty racers, potty racers 3, potty racers 4, potty racers 5 And in two latest versions, his head always turn around for sightseeing, which looks very cute. In the third version, when flying in space, he will get out of the potty spaceship to dance the moonwalk. ![]() In the second version, he has a new hat which is only for pilots. He smiles showing the teeth only when he has safe landing. In the first version, he looks like the description. However, many players think that he is so cute. He is a totally black man with no face, no ear and so on. It makes you glued to them and your victory more worthy.īesides, the main character of the game series is one of the outstanding features that the games have. They are easy to play, easy to control, but very difficult to win. They are so interesting with impressive design, difficult mission and easy control. Playing the other versions, you can be blown away by them. The two first versions’ attraction is the simple design and easy-to-understand rule. This makes you feel curious of all of them and you may play all the five versions. In each version, there are some special features. Therefore, in the third version, you can fly to the space and land on Mars. In four versions, you can upgrade you potty into a potty plane, but in the third version, you can upgrade your potty into a potty spaceship. You can use the money received to buy equipment to upgrade your porta potty. In the three following version, they are the coins or gold that you collect while flying. In the first version and the second version, the amounts of money are what you are awarded for your achievement. ![]() It is not a plane race.Īfter each fly, you will receive an amount of money as reward. The game calculates how far and how high you can fly. Almost the time you play is flying in the sky, but if you are fond of speed, it is not suitable for you. In the games, you play as a guy whose dream is flying to the sky by a porta potty. There are five versions of the game in this series. Potty racers is a game series developed by Gonzo games. Are you waiting for an action game that can make you feel exiting? Are you waiting for an interesting and cute game? You can try playing the series Potty racers.
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![]() Note II: We tried to write our code clean, portable and platform neutral, Packages containing the mentioned headers, on Arch Linux these should be included OpenAL, GLEW/glbinding, Boost, cURL, libogg and libvorbis), you shouldĪlso have development headers installed. Note I: for any of the above listed libraries (OpenGL, SDL2, SDL2_image,
![]() Has a 10% chance of Disorienting the target.Īn odd mechanics point: Disorientation will deny your Templar Rend access, but being set on fire will not, unlike Rangers who lose access to Slash in both cases.Īnyway, Rend is the Templar's bread-and-butter. Has a 5% chance to knock the target back one tile. Killing an enemy with Rend grants 1 Focus. Additionally, performing Rend immediately grants the Templar a bonus action point that by default can only be spent on movement. The Templar has very little use for the Aim stat, so it's a bit surprising how generous their Aim progression is.Ī move-and-melee attack that cannot miss. And I'm not talking melee abilities, here.Īnd of course the whole Focus mechanic is unique to them. These ergonomics could've been thought out better.Īlso weird and not easily intuited from the game's own descriptions is that the Gauntlets -their melee weapon- effectively function as their Psi Amp, in that a few of their abilities tier their effects based on Gauntlet tier. Contributing to the confusion is that if a given target is out of melee range, the game will automatically switch over to such a click prepping an Autopistol shot. Similarly, they're the only class where clicking an alien head icon will result in attempting to target that enemy with a melee attack, which can lead to errors if you're intuitively expecting it to target the enemy with their Autopistol. Their primary weapon is their melee weapon, with one consequence of this being that they are the only class in War of the Chosen that's completely incapable of using Weapon Attachments like Stocks or Scopes. This is one of the bits of War of the Chosen's design that makes me suspect that XCOM 3 is liable to be oriented toward individual missions being a bit lengthier and more enemy-dense, as the Templar's overall design ends up a bit wonky in actual War of the Chosen but would've been decent enough if these kinds of lengthy missions were much more the default -and War of the Chosen's new mission types are biased toward increased length and greater enemy density (Most extremely with Lost-involving missions), it's just they tend to be drowned out by the much wider variety of base-game mission types.Īnyway, the Templar are pretty weird of a class. ![]() In those cases it becomes actually plausible to build up to max Focus, then alternate spending some of it with Rending targets to regain Focus. The Templar's psi wizard abilities tend to perform much better on longer, more enemy-dense mission types, such as Chosen Stronghold assaults, Avenger Defense missions (Whether the original UFO interception version or the new version based on Chosen ambushing the Avenger), or the final mission. This is important because using a Focus-spending skill that also ends the turn means not only does the Templar spend Focus, they also don't gain Focus for abilities like Volt that spend 1 Focus, that effectively doubles the cost unless you happen to be at max Focus anyway. (Said goal being more realistic than you might expect) This means that if the Templar isn't granted an additional turn by Teamwork, Combat Presence, or Inspiration, the Templar expects to only generate 1 Focus per pod, and so expects to only fight 1-2 pods at max Focus. Part of the problem is how the numbers are tuned: a typical XCOM 2 mission has 3-4 enemy pods, and the ideal goal of a player is to activate each pod separately from the rest and kill each pod before any members get a chance to do anything. In practice, the Templar ends up with an incredibly strong melee game, potentially a decent Autopistol game, while their psi wizard abilities tend to end up situational and rarely-used, in no small part because they consistently cost Focus and are rarely tuned to be worth sacrificing that and giving up the benefits of just Rending things. The Templar is probably the bluntest example of class hybridization, being a melee Ranger hybridized with a Psi Operative and given some Sharpshooter Pistol-slinging on the side. ![]() The app can be loaded on OS startup, especially helpful for those who forget to keep the program open.īeeBEEP is a helpful application that can be integrated into plenty of scenarios, as long as these are somehow tied to a Local Area Network, and there is a need for communication amongst the users connected to it. Alerts can be tweaked to alarm the user in case any messages are received via this platform. You can also create a profile, adding information relevant to yourself.Īn icon or picture can be associated with the profile to make the user more recognizable. Since we're talking about a chat app, the program comes with specific tools that can alter your interaction with any of the available peers. Lets honor her life today, and every day and continue to call for JusticeforBre. If that does not work, clear the app’s data and cache. Breonna Taylor should have been celebrating her birthday yesterday. After that, hold down the Power Button and tap on Restart. This makes the app a great way to share important information with your co-workers, for example. To force close the messages app, simply go to the apps list in the Settings menu and tap on the messages app, then tap on the Force stop button. It does not require any external server to work as it works directly in your LAN using AES with random 256-bit key generated for every single point-to-point connection made. There's a dedicated button for chatting with all users on your list. BeeBEEP is a free peer-to-peer lightweight LAN messenger that allows you to exchange encrypted messages and files with your office workers in a snap. It allows simple chat-style instant messaging, group chats, friend lists, and exchanging files. The following, smaller areas are for viewing users and all chats you might have participated in. ![]() The first area and the biggest is a dedicated chat space. BeeBEEP games can be downloaded from SourceForge. BeeBEEP note: From version 3.0.2 on BeeBEEP comes in two flavours- Qt4 (for Windows XP) & Qt5. The main window of the program is split into four parts. BeeBEEP source code can be downloaded from SourceForge. ![]() It's not old, but at the same time, it's not breathtaking either. This is why it is a good time to see how to install it on Ubuntu 16.04, Ubuntu 17.04, Linux Mint 18 and derivatives. This can lead to multiple re-renders and is probably the cause for seeing the alert behaviour multiple times. Hardware Appliance display for the message Factory Reset: Reboot Required. This application has reached its version 4.0.0 a short time ago. Move onDropdownChange from the render function, as its going to get called every time the component is re-rendered. During that time, the boot progress is displayed in the front panel display. The application itself doesn't look any different from various other similar programs. BeeBEEP is an open-source, cross-platform program and a Messenger Lan peer to peer. This means that all users have to be on the same network to interact with each other. The application was designed to function on LAN or Local Area Connection. It might look like a simple chat client, but it hides a very complex application that benefits from not being exactly mainstream. This particular program is a nice bundle of options and functions offering such features. Import Alert from Dropdown from default class Header extends React.BeeBEEP might not have an easy-to-understand name, but it manages to offer users helpful functionality for situations where you'd like to chat with other members of your network in a safe environment, free from any dangers, and also open to file sharing and transfers. The Alert is called in the child component and the child is called in the parent: //Parent Also in the dropdown change method, that API should be called and will return maybe has returned value true (If has returned true, the Alert should be hide). BeeBEEP is the free office messenger that is indispensable in all those places where privacy and security are an essential requirement. I can do that but for some reason, in the UI I’m getting alert displayed 2x. I’m trying to display Alert message if API return false. ![]() There is also correspondence concerning John J. Collection contains Ancell family correspondence, 1840-1885, concerning family matters and family health and illness. Ancell and a military commission from Governor Henry A. Ancell (1831-1894) received from and sent to family members, friends, and other soldiers and concerning family matters, camp conditions, troop movements, and the weather. Includes the Civil War letters, 1862-1865, of John J. Correspondence principally concerns Ancell, Pettit and Winn family matters and business transactions and the Civil War. Papers, 1788-1909, of the Ancell family and related families of Fluvanna County, Virginia and Ohio, containing accounts, articles of agreement, Bible records, a military commission, deeds, genealogical notes, letters, military orders, a plat, promissory notes, and receipts. Includes a black and white photograph of Reverend Hollister and a photograph of the original framed receipts collected by him. Most of the receipts relate to wages received in the House of Burgesses, House of Delegates, Privy Council, etc. Included are certificates signed by the following individuals: John Randolph, Charles Tompkins, Thomas Jefferson, John Montgomery, John Marshall, William Wirt, James Monroe, B Stark, Edward Carrington, Robert Vance, John Washington, and Richard Lee. According to a note by the donor, Gloria Hollister Anable, her paternal grandfather found the signatures in receipt books in the Virginia State House and sent them back home to Stamford, Connecticut. Miscellaneous receipts, 1770-1783.Ĭollection of Gloria Hollister Anable containing of several receipts signed by prominent Virginia statesmen of the 18th century which were collected by Union Chaplain Reverend Philander Hatch Hollister of the 29th Connecticut Infantry following the Confederate evacuation of Richmond. First 10 pages of the volume is a business ledger, 1816-1817, possibly of Benjamin Bragg of Amelia County.Īnable, Gloria H. Also a list of names with numbers beside them, possibly indicating number of slaves owned. ![]() Loose papers include circulars requesting full accounts of all male free blacks, of all slaves impressed in the county and a request to post notices as soon as possible. ![]() Also recorded was a list of deserters and absentees in Amelia County, list of persons forwarded to Camp Lee in Petersburg monthly reports providing lists of conscripts, persons exempt, and deserters. Lists include date of enrollment, name, age, occupation, birth place, height, eye color, hair color, skin complexion, and how disposed i.e, whether exemption was approved or disapproved, reason for exemption, whether detailed or not. 1 volume (84 pages).Īmelia County Militia enrollment records and unidentified cash account ledger, 1816-1817, 1864, contains a militia enrollment ledger, 1864, containing enrollment lists of persons eligible for militia service, including persons who applied for exemption from militia duty, persons applied to be detailed, persons exempt from militia duty on the basis of number of slaves owned or occupation, list of conscripts in Amelia County, and a list of free negroes. Militia Enrollment Records and Unidentified Cash Account Ledger, 1816-1817, 1864.Īccession Local Government Records, Amelia County. Also includes letters relating to the New York State Bank (Albany, N.Y.) and the First and the Second Banks of the United States, especially their Virginia branches, as well as applications to the First and Second Banks of the United States for branches in Fredericksburg and Lynchburg, Virginia.Īmelia County (Va.) Militia. Read of the 1st Virginia Artillery describing earlier stages of the Gettysburg campaign. Sutton letters, including letter from William M. There are items relating to the Civil War, including financing of the Confederate army, civilian relief, and blockade-runners. Microfilm.īusiness correspondence and documents, 1841-1879, from various Virginia regional banks, consisting of correspondence and documents related to the Clarksville branch of the Exchange Bank of Virginia correspondence of Savings Institution of Richmond (1828- 1841), Pittsylvania Savings Bank (1861-1864), William M. ![]() Interested in sponsoring developer content? Message on twitter for details. If you like what you see, don’t forget to follow me on twitter check out my GitHub, and subscribe to my blog to learn more mobile developer tips and tricks! More meaningful and useful content coming soon! Including more Alexa, Dialogflow, Google Assistant, Bixby, Cortana, and of course Xamarin work □ If this didn’t help you or isn’t why your App icon isn’t showing up, here are some links I’ve used in the past: csproj if you use MakeAppIcon and save yourself some time. Long story short – copy paste this into your. But if you bring in your icons from any outside source, be sure to make sure you add them in the. Normally, if you drag and drop or file select within Visual Studio to set the images for your app icon, this is done for you. csproj file to make sure all the images and their full paths are included – not just the AppIcon.appiconset. ipa – so we need to actually update our ios project’s. Turns out VS uses the Content.json to read the images to show in your assets, but this does not actually include them in any sort of build output to your final. So all you have to do is take the AppIcon.appiconset and drop it in your Assets.xcassets and you’re off and running. ![]() This Contents.json is also what Visual Studio uses to show you the icons in your Assets.xcassets. Usually the designer on my team will send me the exact icons exported to the specific sizes, but they were on vacation and I wanted to make some progress! I 100% recommend using MakeAppIcon for those who haven’t discovered it yet.įor those that haven’t used it, MakeAppIcon gives you a zip with the actual AppIcon.appiconset which includes every size you need and their registration in the Contents.json which tells the build agent what images fit which profile/size. One thing I did differently this time around was use to generate my individual icons from a single high resolution image. So, if you’re new to Xamarin development or iOS development in general, the above steps are definitely the first things to try! Finally, click OK at the bottom of the Edit File Type window, and you’re done all of the icons for that file type will have changed. Try on another machine, repeat above steps Click Browse in the corner of the popup, navigate to your new icon, click it, then click OK.Check that my ist was pointing at my AppIcon.Check that the actual AppIcon had all the images filled in.Check that the AppIcon asset was in the Assets.xcassets.I had seen this before, so I double checked everything and tried all my old tricks: The issue – I created an AppIcon for my iOS app, and it simply won’t show up on any device or simulator. I find myself spending less and less time dealing with workarounds for Xamarin issues, filing bug reports, or getting frustrated at not understanding why something isn’t working. In the age of Xamarin Hot Reload and Hot Restart, we are beginning to get spoiled with the tooling we use every day. Meadow.Tip – Playing Jingle Bells with a Piezo Speaker Using C#.Navigate to HKEYCLASSESROOT > Local Settings > Software > Microsoft > CurrentVersion > TrayNotify. Xamarin.Tip – Fixing Missing iOS App Icons Here is how to use the Registry Editor to fix missing icons on the taskbar: In the Start menu search bar, search for registry editor and select Run as administrator.Xamarin.Tip – iOS Push Notification Device Token Extraction in iOS 13+.It can also affect the system performance especially when you have lot of app icons on the desktop.īelow is how the desktop icons will look with the default drop shadow effect in Windows 11.Drop shadow can make the icon text unreadable in some cases and you want to get rid of that.You may have a vision problem or get irritated when looking text with shadows.The desktop theme and icons may not blender smoothly.You have cluttered desktop filled with plenty of icons and need to search for an app to open.However, the shadow effect may disturb in the following situations: In general, it will look good, and you will not find any difference in icons with or without text shadow. ![]() In this article, we will explain how to remove drop shadow from desktop icon labels in Windows 11 to look them cool for your eyes. You can notice a shadow below the icon text and comes as a default function. Renaming AppIcons to AppIcon did the job. ![]() Friday, Aug7:13 AM 0 Sign in to vote User16951 posted +1 to MahibaRajaseelan answer. Open ist designer and under 'Visual Assets' tab, Choose 'AppIcons' source in App Icons. One such a problem is the drop shadow showing for desk icon labels. if required, delete the app in simulator/device and run. However, it carries over some of the annoying stuffs offered in previous Windows 10 versions. Drag the app to the Home screen page, lifting your finger to place the app. Long-press the app icon you want to add to the Home screen. Touch the Apps icon to display the Apps drawer. The screen must have room for the app icon. Windows 11 offers a completely new interface compared to previous versions. Here’s how that works: Visit the Home screen page on which you want to stick the app icon. ![]() You’ll also use Amazon S3, Amazon EC2, Amazon Kinesis Data Firehose, Amazon Kinesis Data Analytics, Amazon Elasticsearch Service to create a data ingestion pipeline with the use of high-scale AWS Managed services. In Introduction to Designing Data Lakes, you’ll use Amazon S3, Amazon OpenSearch Service, AWS Lambda and Amazon API Gateway to create an Amazon OpenSearch Service Cluster. In Architecting Solutions on AWS, you’ll use Amazon API Gateway, AWS Lambda, Amazon SQS, Amazon DynamoDB, and Amazon SNS to build a serverless web backend. Through 15 hands-on labs, you’ll use the AWS Management Console to apply skills learned in the videos. white papers and product FAQs) on the AWS Certified Solutions Architect - Associate exam page to understand what content and services are covered by the exam. To prepare for your AWS Certification exam, we recommend that - in addition to attaining this professional certificate - candidates review the free exam guide, sample questions, and AWS technical documentation (e.g. Per Enterprise Strategy Group, surveyed AWS Certification holders credited their certification for their higher earnings (74%), increased confidence (87%), and increased influence among coworkers (79%). This AWS Certification is one of the top-paying IT certifications, per the SkillSoft IT Skills and Salary report. The certification focuses on the design of cost and performance optimized solutions and demonstrating a strong understanding of the AWS Well-Architected Framework. The AWS Certified Solutions Architect – Associate certification showcases knowledge and skills in AWS technology across a wide range of AWS services. You will start by learning key AWS Services for compute, storage, database, networking, monitoring, and security, then dive into how to design architectural solutions, how to create and operate a data lake, and how to prepare for the certification exam. This professional certificate provides the knowledge and skills you need to start building your career in cloud architecture and helps you prepare for the AWS Certified Solutions Architect - Associate exam. ![]() We realize that many beginners with little to no knowledge about terms like encoding and bitrate might want to venture into streaming. Depending on your system configuration, hardware, and internet bandwidth you will have to alter the OBS settings to get the best results. ![]() Unfortunately, it is not as straightforward as we had hoped it would be. ![]() All you have to do is make some specific tweaks to optimize the OBS settings. Here comes in OBS, short for Open Broadcaster Software - a popular streaming software that can potentially alter your streaming quality. The content that you choose to post is extremely important, but the quality of your streams can make or break your streaming career. But there is definitely a learning curve involved to become a pro at live streaming. Now, you don’t have to be a tech-savvy genius to create your own streaming channel on Twitch. Now, with platforms like Twitch, offering users a medium to live stream and establish their own brand, streaming is totally becoming a viable career option.Įspecially for gamers, as they have literally taken over the streaming medium somehow proving that there is a surprisingly huge viewership base for gaming-related content. You can live stream games, conduct virtual music concerts, create your own cooking streams or art tutorials. Live streaming your content online is one of the best ways to establish an online presence and create a huge base of viewers that love your content. Written by: Hrishikesh Pardeshi, Founder at Flexiple, buildd & Remote Tools. Access tutorials on the Studio YouTube channel and get updates directly in your inbox by subscribing to the Studio newsletter. Livestreams, voice chats and video calls look and sound better with powerful AI effects like eye contact, noise and room echo removal, virtual background and more.įollow NVIDIA Studio on Instagram, Twitter and Facebook. NVIDIA Broadcast, part of the exclusive NVIDIA Studio suite of software, transforms any room into a home studio. GeForce RTX users can stream higher-quality images at the same bitrate as competitive products or encode at a lower bitrate while maintaining a similar picture quality. Comparison of 4K image quality in AV1 livestream 1.ĭesigned to support the rigors of professional content creators, NVENC preserves video quality with a higher accuracy than competitive encoders. A boon to streamers, NVENC offloads compute-intensive encoding tasks from the CPU to dedicated hardware on the GPU. GeForce RTX 40 Series GPUs usher in a new era of high-quality streaming with AV1 encoding support on the eighth-generation NVENC. Better Streams With NVENC, NVIDIA Broadcast Learn how to configure OBS Studio for streaming AV1 with GeForce RTX 40 Series GPUs in the OBS setup guide. Enhanced RTMP ingestion has been released as a beta feature on YouTube. The enhanced protocol also adds support for HEVC streaming, bringing new formats to users on the existing low-latency protocol they use for H.264 streaming. Support for AV1 on YouTube comes through the recent update to RTMP. Even in network-limited environments, streamers can now reap the benefits of high-quality video shared with their audience. ![]() The previous standard for livestreaming, H.264, usually maxed out with 1080p at 60 fps at the commonly used bitrates of 6-8 Mbps, and often produced blocky, grainy images.ĪV1’s increased efficiency enables streaming higher-quality images, allowing creators to stream at higher resolutions with smoother frame rates. This work was necessitated by gamers and online content creators who pushed the boundaries of old formats that were defined roughly 20 years ago. AV1 - The New StandardĪs a founding member of the Alliance for Open Media, NVIDIA has worked closely with industry titans in developing the AV1 codec. For example, AV1 enables streaming 4K at 60 frames per second with 10 Mbps upload bandwidth - down from 20 Mbps with H.264 - making 4K60 streaming available to a wider audience. At higher resolutions, AV1 encoding is even more efficient. This reduces the upload bandwidth needed to stream, a common limitation from streaming services and internet service providers. This latest software update adds support for AV1 streaming to YouTube over Enhanced RTMP.Īll GeForce RTX 40 Series GPUs - including laptop GPUs and the recently launched GeForce RTX 4070 - support real-time AV1 hardware encoding, providing 40% more efficient encoding on average than H.264 and delivering higher quality than competing GPUs. AV1, the next-generation video codec, is expanding its reach with today’s release of OBS Studio 29.1. ![]() VIP packages, general admission weekend passes and travel packages are on sale now through Single-day tickets will go on sale in the coming weeks. New this year, the Cultural Exchange Village comes to life outside the performance tent with artist demonstrations, daily parades and sampling of traditional Puerto Rican dishes. Puerto Rican bomba, plena, salsa and reggaeton rhythms will echo across the Festival grounds on various stages, and inside the Cultural Exchange Pavilion. Jazz Fest celebrates Puerto Rico in 2023 with colorful artist demonstrations, live music and dance showcases, parades, cultural displays, photo exhibits and authentic cuisine. ![]() Chief Joseph Boudreaux Jr., Original Pinettes Brass Band, New Orleans Nightcrawlers, Josh Kagler & Harmonistic Praise Crusade, New Breed Brass Band, Sisters of Unity and Untouchables Social Aid & Pleasure Clubs, plus hundreds more artists scheduled to appear. Bobby Jones, The City of Love Music Ministry, The Rumble feat. Michael White, La Tribu de Abrante, Atabal, Plena Libre, and Pirulo y la Tribu of Puerto Rico, 79rs Gang, Anthony Brown & Group TherAPy, Charlie Sepulveda & The Turnaround, Ronnie Lamarque, Maggie Koerner, Eric Lindell, DJ Shub presents War Club Live, Dr. John Boutté, Little Freddie King, Andrew Duhon, Shamarr Allen, Artemis, Glen David Andrews Band, Leyla McCalla, John Mooney & Bluesiana, James Andrews & the Crescent City Allstars, Tribute to Ma Rainey, Low Cut Connie, Catherine Russell, Luther Kent & Trickbag, Curley Taylor & Zydeco Trouble, Continental Drifters, Lost Bayou Ramblers, Cha Wa, Charlie Gabriel and Roger Lewis, Bassekou Kouyate of Mali, RAM of Haiti, Hot 8 Brass Band, Tribute to Sidney Bechet featuring Donald Harrison Jr. & Runnin’ Pardners, Marcia Ball, Christian McBride’s New Jawn, Charlie Musselwhite, Davell Crawford, Martha Redbone, Durand Jones, Nicholas Payton, Nathan & Zydeco Cha Chas, Eric Gales, Larkin Poe, Allison Russell, Dee Dee Bridgewater, Sweet Crude, Big Chief Donald Harrison Jr., Mdou Moctar of Niger, The Campbell Brothers, Morgan Heritage, Big Chief Monk Boudreaux & the Golden Eagles, David Shaw, Big Sam’s Funky Nation, Honey Island Swamp Band, Mississippi Mass Choir, The 2023 Festival weekend dates are April 28 – 30 and May 4 – 7.Īrtists scheduled to appear at the 2023 Jazz Fest include:ĭead & Company, Ed Sheeran, Lizzo, Mumford & Sons, The Lumineers, Santana, Jon Batiste, Jill Scott, Robert Plant & Alison Krauss, Kane Brown, H.E.R., Steve Miller Band, Tedeschi Trucks Band, Gary Clark Jr., Leon Bridges, Farruko, Ludacris, Trombone Shorty & Orleans Avenue, Kenny Loggins, Wu-Tang Clan + The Soul Rebels, The Revivalists, Jazmine Sullivan, Herbie Hancock, NE-YO, Big Freedia, Tom Jones, Buddy Guy, Irma Thomas, Melissa Etheridge, Galactic featuring Anjelika ‘Jelly’ Joseph, Mavis Staples, Jamie Cullum, Tab Benoit, Taj Mahal Quartet, Marcus King, Cory Wong, Los Lobos, Keb’ Mo’, Preservation Hall Jazz Band, Anders Osborne, Samantha Fish, Cyril Neville, Terence Blanchard featuring The E-Collective & Turtle Island Quartet, Tank and The Bangas, Angelique Kidjo, Dumpstaphunk, Rebirth Brass Band, Maze featuring Frankie Beverly, John Hiatt & the Goners, The Radiators, Robert Randolph Band, Hurray for the Riff Raff, Ivan Neville’s Dumstaphunk, Durand Jones, Zigaboo Modeliste & The Funk Revue, The Dirty Dozen Brass Band, Leo Nocentelli, Kermit Ruffins & the Barbecue Swingers, Molly Tuttle & Golden Highway, George Porter Jr. Almost half a million fans gather annually for the seven-day event that features virtually every style of American music from over 5,000 musicians spread across 14 different music stages at the Fair Grounds Race Course. Jazz Fest is an annual celebration of the unique culture and heritage of New Orleans and Louisiana, alongside unforgettable performances by nationally and internationally renowned guest artists to create one of the world’s most diverse musical festival lineups. New Orleans, LA (January 13, 2023)-The New Orleans Jazz & Heritage Festival presented by Shell today announced the music lineup for the 2023 event, scheduled for April 28 – May 7. Weekend Passes and VIP Packages on Sale Now! To Appear at the 2023 New Orleans Jazz Fest April 28 – May 7 ![]() Jon Batiste, Jill Scott, Robert Plant & Alison Krauss, Kane Brown, H.E.R., Steve Miller Band, Tedeschi Trucks Band, Gary Clark Jr., Leon Bridges, Trombone Shorty & Orleans Avenue, Dead & Company, Ed Sheeran, Lizzo, Mumford & Sons, The Lumineers, Santana, ![]() Approval of pembrolizumab for treating MSI-H/dMMR cancers While this can potentially become an alternative molecular test, with the advantage of simultaneous testing of TMB and other actionable gene mutations and optimization of tumor tissue usage, it is important to highlight that these tests should be performed at validated laboratories. More recently, the use of NGS panels has been validated for MSI-H diagnosis, and the reported concordance rates between NGS testing and IHC or PCR are both high 17, 18. Frequently, clinical trials that assessed MSI/MMR status used both IHC and PCR methodologies. In fact, pentaplex PCR is the preferred panel given its higher sensitivity and specificity 13, 16. Tumors with instability at 2 or more of these markers are defined as MSI-H 10, 12, 14, 15. This can be done using two panels: The National Cancer Institute (NCI) panel, which evaluates two single nucleotide repeat loci, BAT-25 and BAT-26, and three dinucleotide repeat loci, D2S123, D5S346 and D17S250 and pentaplex PCR, using five poly-A mononucleotide repeats (BAT-25, BAT-26, NR-21, NR-24, and NR-27). The assessment of microsatellite alterations using classical PCR-based methodology combined with fragment length analysis is usually performed with DNA samples from tumors and paired normal DNA. In cases of indeterminate IHC results, a molecular test preferentially based on PCR is indicated 13. Importantly, while there is a strong recommendation for performing IHC for all tumors belonging to the spectrum of Lynch syndrome, there are insufficient data for definitive recommendations in breast cancer. If IHC expression of at least one of those proteins is lost, the diagnosis of dMMR is established. dMMR by IHC is defined by the absence of nuclear staining of some of the abovementioned MMR proteins in the tumor with preserved internal positive cell controls 10. IHC for the MMR proteins MLH1, MSH2, MSH6, and PMS2 is a practical and widely available methodology among pathology laboratories. #Treatment with the designated agnostic therapy should be started during the course of therapy for patients with the target biomarker who have progressed following prior treatment, and no satisfactory alternative treatment options are available. †NGS should be performed preferentially at validated laboratories. *In cases of negative IHC for dMMR in breast cancer, confirmatory PCR or NGS could be performed. IHC: immunohistochemistry FFPE: formalin-fixed, paraffin-embedded FISH: fluorescence in situ hybridization MBC: metastatic breast cancer NGS: next-generation sequencing PCR: polymerase chain reaction. For those patients harboring any of these three biomarkers who have progressed following prior treatment and who have no satisfactory alternative treatment options, we recommend the use of the appropriate tissue-agnostic approved therapy. In the case of TMB, blood samples can be collected to perform liquid biopsy-based NGS panels. 1).įollowing the diagnosis of metastatic breast cancer, formalin-fixed, paraffin-embedded (FFPE) tissue blocks from archival tissue or from a new tumor biopsy should be used to evaluate the status of one of the three discussed biomarkers: MSI, TMB-H, or NTRK fusions. In 2020, the FDA expanded pembrolizumab approval to a new tissue-agnostic indication: high tumor mutational burden (TMB-H) 5 (Fig. The first tissue-agnostic treatment approval was granted by the FDA to pembrolizumab in patients with high microsatellite instability (MSI-H) tumors in 2017, followed by larotrectinib and entrectinib for the treatment of cancers harboring NTRK fusions in 20, respectively 4. Novel oncogenic drivers and biomarkers have been described across different tumor types, leading to the development of targeted therapies and the design of innovative trials, many of which are evaluating tissue-agnostic therapies 3. With the emergence of next-generation sequencing (NGS) tools, cancer genomic data have become more widely available, and cancer therapy has shifted from a purely histology-based approach toward incorporating a precision medicine-based approach. Although substantial progress in treatment has been made, metastatic breast cancer (MBC) remains an incurable disease, and the 5-year survival rate for stage IV breast cancer is approximately 25% 2. Breast cancer (BC) represents the most frequently occurring cancer and is the leading cause of cancer-related deaths among female patients worldwide 1. |